Original title: おっぱいハート～彼女はケダモノ発情期ッ!?～
Ryuuya has an older sister, Miya. He lives a peaceful school life with his friends. But one day, he and his friends accidentally drink a medicine juice. Once you drink it, you'll become sexually sensitive and get sexually excited soon. Especially the breasts of the girls who drink it will get bigger and they will need to have sex to cool down. Also, to make a vaccine, they will need to get pregnant. Like this, Ryuuya starts having sex with the girls to cool them down and make a vaccine...!